Method of promoting nitrogen retention in humans
AssigneesIowa State University Research Foundation, Inc., Vanderbilt University
InventorsSteven L. Nissen, Paul J. Flakoll, Naji N. Abumrad
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Abstract
Nitrogen retention in human subjects is promoted by administering .beta.-hydroxy-.beta.-methylbutyric acid (HMB). The amount of HMB administered is effective to conserve protein as determined by reduction in urinary nitrogen. The method can be used with patients having a negative nitrogen balance due to disease conditions, and also with normal elderly persons who are subject to protein loss. The HMB may be administered orally or by intravenous infusion.
Claims14
The method of protein sparing, comprising orally or intravenously administering to a human subject an effective amount of .beta.-hydroxy-.beta.-methylbutyric acid (HMB) for increasing the retention of nitrogen, said HMB being in an edible or intravenously-administrable form selected from (i) its free acid form, (ii) its sodium, potassium, or calcium salt, (iii) its methyl or ethyl ester, or (iv) its lactone, and continuing the said administration of HMB until the amount of nitrogen in the patient's urine has substantially decreased.
The method of treating an adult human patient having a negative nitrogen balance, comprising orally or intravenously administering to the patient from 0.5 to 10 grams per 24 hours of .beta.-hydroxy-.beta.-methylbutyric acid (HMB) based on its calcium salt, said HMB being in an edible or intravenously-administrable form selected from (i) its free acid form, (ii) its sodium, potassium, magnesium, or calcium salt, (iii) its methyl or ethyl ester, or (iv) its lactone, and continuing the said administration of HMB until the loss of nitrogen is substantially reduced as determined by nitrogen analysis of the patient's urine.
The method of improving protein nutrition in elderly human subjects, comprising including in the daily diets of the human subjects an amount of from 0.5 to 10 grams per 24 hours of .beta.-hydroxy-.beta.-methylbutyric acid (HMB) based on its calcium salt, said HMB being in an edible form selected from (i) its free acid form, (ii) its sodium, potassium, or calcium salt, (iii) its methyl or ethyl ester, or (iv) its lactone, said amount of said HMB incorporated in said diets being effective to reduce the urinary nitrogen losses of the subjects.
The method of treating a human patient who is receiving an intravenous therapy and is subject to excessive loss of nitrogen, comprising incorporating in an intravenous solution being given to the human patient an effective amount of HMB for reducing urinary nitrogen, said HMB being in an intravenously administerable form selected from Ca-HMB or Na-HMB.
Dependencies are inferred from the claim text.