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US 5,348,977 AGranted
Cobalt complexes as anti-cancer agents
AssigneeWarner-Lambert Company
InventorsWilliam A. Denny, Brian D. Palmer, David C. Ware, William P. Wilson
Life of this patent
Estimating the term…
Abstract
New cobalt complexes of nitrogen mustard alkylating agents which have been found to have hypoxia-selective antitumour properties and are thereby useful antitumour agents are described.
Claims11
A compound represented by either of the general formulae (I) and (II):
- ##STR7## where X and Y separately represent H, lower alkyl (optionally substituted with hydroxy and/or amino functions) containing from 1 to 6 carbon atoms, or phenyl;
- R represents H, lower alkyl (optionally substituted with hydroxy and/or amino functions), phenyl (optionally substituted with Me, OQ, CONHQ and/or NHCOQ, where Q is lower alkyl optionally substituted with hydroxy and/or amino functions and containing from 1 to 6 carbon atoms) or halogen, and Z.sup.- is Cl.sup.-, Br.sup.-, I.sup.-, ClO.sub.4.sup.-, NO.sub.3.sup.-, HCO.sub.3.sup.- or any other pharmaceutically-acceptable organic or inorganic counterion.
Dependencies are inferred from the claim text.