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US 5,348,973 AGranted
Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
AssigneeRhone-Poulenc Chimie
InventorsMuppala S. Raju, Namdol Huh
Life of this patent
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Abstract
Hydroxychroman-2-carboxylic acid esters can be resolved by enantiospecific hydrolysis by the use of liver enzymes, particularly solvent treated (acetone) enzymes. Liver enzymes from calf, cat, dog, eel, goat, lungfish, mouse, rat and seal have been found to be enantiospecific.
Claims44
A process for resolving by enantiospecific hydrolysis carboxylic acid esters which are the methyl or ethyl esters of 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid comprising the step of
- hydrolyzing said esters with an animal liver enzyme derived from an animal selected from the group consisting of calf, cat, dog, eel, goat, lungfish, mouse, rat and seal;
- wherein percent acid produced upon hydrolysis is at least about 26% and percent enantiomeric excess of said resolved acid is at least about 8%.
Dependencies are inferred from the claim text.