Diphenyloxazolyl-oxazoles as platelet aggregation inhibitors

Abstract

A novel series of oxazole derivatives having enhanced water solubility bioavailability and metabolic stability is disclosed in the Formula I ##STR1## Y is CH.sub.3, Ph, or OH, provided that when Y is OH, the compound exists in the keto-enol tautaumerism form ##STR2## R.sup.1 is Ph or Th; R.sup.2 is H or CH.sub.2 R.sup.3 ; R.sup.3 is H, OCH.sub.3, C.sub.1 -C.sub.5 lower alkyl, or CO.sub.2 R.sup.4 ; R.sup.4 is H or C.sub.1 -C.sub.5 lower alkyl; R.sup.5 is H or CH.sub.3 ; R.sup.6 is OHCHN or H.sub.2 N; and R.sup.7 is H or OH; or pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of ADP-induced blood platelet aggregation in human platelet-rich plasma.

Dependencies are inferred from the claim text.