4-oxoquinoline-3-carboxylic acid derivatives and their use

A compound of formula (I):

• ##STR20## in which R.sup.1 represents a methoxy group having at least one fluorine substituent;
• R.sup.2 represents groups of formula (III):
• ##STR21## in which:
• R.sup.6 represents a hydrogen atom;
• a C.sub.1 -C.sub.6 alkyl group;
• a substituted C.sub.1 -C.sub.6 alkyl group having at least one substituent selected from the group consisting of substituents (b), defined below;
• a hydroxy group;
• a C.sub.1 -C.sub.6 alkoxy group;
• or a C.sub.1 -C.sub.6 alkoxy group having at least one fluorine substituent;
• R.sup.7 represents a group of formula R.sup.8 R.sup.9 N-(CH.sub.2).sub.q -. in which R.sup.8 and R.sup.9 are independently selected from the group consisting of hydrogen atoms, C.sub.1 -C.sub.6 alkyl groups and aralkyl groups, and q represents 0 or 1;
• a hydroxy group;
• or a C.sub.1 -C.sub.6 alkoxy group;
• B represents a methylene group, an ethylene group, a trimethylene group, or a tetramethylene group;
• and
• n represents 1 or 2;
• substituents (b) are selected from the group consisting of:
• hydroxy groups, C.sub.1 -C.sub.6 alkoxy groups, and halogen atoms;
• and
• said aralkyl groups have from 1 to 4 carbon atoms in the alkyl part and have an aryl part which has from 6 to 10 carbon atoms and which is unsubstituted or has at least one substituent selected from the group consisting of substituents (c), defined below;
• substituents (c) are selected from the group consisting of:
• hydroxy groups, C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups, C.sub.2 -C.sub.6 aliphatic acyloxy groups, C.sub.2 -C.sub.6 aliphatic acyl groups, carboxy groups, C.sub.2 -C.sub.6 alkoxycarbonyl groups, sulfo groups, nitor groups, cyano groups, amino groups, C.sub.2 -C.sub.6 aliphatic acylamino groups, and mono- and di-(C.sub.1 -C.sub.6 alkyl) substituted amino groups;
• or a pharmaceutically acceptable salt, ester or amide thereof.