Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives

Abstract

A series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones having enhanced water solubility bioavailability and metabolic stability is disclosed in the Formula I ##STR1## wherein R.sup.1 is H, or C.sub.1 -C.sub.4 lower alkyl; R.sup.2 is H, or (CH.sub.2).sub.m R.sup.3 ; R.sup.3 is tetrahydro-2H-pyranyl, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.8 cycloalkyl, or substituted or unsubstituted phenyl, wherein the substituents are halogen, alkoxy, or trifluoromethyl; m is an integer of 1-3; and n is an integer of 1-5; or pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of ADP-induced blood platelet aggregation in human platelet-rich plasma.

Dependencies are inferred from the claim text.