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US 5,348,940 AGranted
Cyclohexapeptidyl hydroxypropionitrile compounds
AssigneeMerck & Co., Inc.
InventorsJames M. Balkovec, Robert A. Zambias
Life of this patent
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Abstract
Certain propionitrile compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described. A novel process for their preparation is also described. ##STR1##
Claims9
A compound having the formula:
- ##STR11## wherein R.sub.1 is H or OH
- R.sub.2 is H or OH
- R.sub.3 is H, OH or OR where R is C.sub.1 -C.sub.4 alkyl or benzyl
- R.sub.4 is H or OH
- R.sub.5 is H, OH or CH.sub.3
- R.sub.6 is H or CH.sub.3, and
- R.sup.I is C.sub.9 -C.sub.21 alkyl, C.sub.9 -C.sub.21 alkenyl, C.sub.1 -C.sub.10 alkoxyphenyl, or C.sub.1 -C.sub.10 alkoxynaphthyl.
4 more elements
Dependencies are inferred from the claim text.