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AssigneesNew York Blood Center, Inc., JCR Pharmaceuticals Co., Ltd., Santen Pharmaceutical Co., Ltd.
InventorsBernard Horowitz, Richard W. Shulman, Adrianne J. Setton, Toyohiko Nishimura, Yoichi Kawashima
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A stable and soluble multi-dose ophthalmic solution is disclosed. The solution contains fibronectin, an amino acid, a sugar, and a lower alkyl p-hydroxybenzoate. A method of treatment of ophthalmic wounds employing the ophthalmic solution, a process for preparing fibronectin for ophthalmic use, a method of lyophilizing an aqueous solution of fibronectin free of albumin, a method for inhibiting bacterial growth in an ophthalmic solution while preserving the cellular adhesion and wound healing activities of fibronectin, and a method of treatment of ophthalmic wounds administering a wound-healing accelerator solution are also disclosed.
A stable and soluble multi-dose ophthalmic solution comprising a therapeutically effective amount Of fibronectin, an amino acid selected from the group consisting of water-soluble hydrophilic amino acids and mixtures thereof, a sugar selected from the group consisting of a monosaccharide, a disaccharide, a trisaccharide, a polysaccharide, derivatives thereof, and mixtures thereof, and a lower alkyl p-hydroxybenzoate preservative, said ophthalmic solution being free of albumin.
A method for inhibiting bacterial growth in an ophthalmic solution comprising fibronectin, an amino acid selected from the group consisting of water-soluble hydrophilic amino acids and mixtures thereof, and a sugar selected from the group consisting of a monosaccharide, a disaccharide, a trisaccharide, a polysaccharide, derivatives thereof, and mixtures thereof, while preserving the cellular adhesion and wound healing properties of fibronectin, said method comprising adding to said ophthalmic solution a lower alkyl p-hydroxybenzoate preservative in an amount sufficient to inhibit bacterial growth in said ophthalmic solution.
Dependencies are inferred from the claim text.