DNA encoding TRKC protein
AssigneeE. R. Squibb & Sons, Inc.
InventorsMariano Barbacid, Fabienne Lamballe
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Abstract
Nucleic acid sequences, particularly DNA sequences, coding for all or part of a trkC protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a trkC protein and methods for producing these polypeptide molecules.
Claims18
An isolated nucleic acid molecule coding for a trkC protein wherein said nucleic acid is selected from the group consisting of:
- (a) a nucleic acid comprising a nucleic acid sequence coding for the amino acid sequence of FIGS 1B and 1C (SEQ. ID. NO.:2) and
- (b) a nucleic acid capable of hybridizing to the complement of a nucleic acid according to (a) above under stringent conditions.
An expression vector comprising a DNA coding for a trkC protein wherein said DNA is selected from the group consisting of:
- (a) a DNA having a sequence coding for the amine acid sequence of FIGS. 1B and 1C (SEQ. ID. NO.:
- 2) and
- (b) a DNA capable of hybridizing to the complement of a DNA according to (a) above under stringent conditions.
A method for detecting a nucleic acid encoding all or part of a trkC protein or a related nucleic acid comprising contacting the nucleic acid with a detectable marker having a sequence of at least 15 sequential nucleotides complementary to the nucleic acid sequence of FIGS. 1B and 1C (SEQ. ID. NO.:
- 1 ) under conditions which permit binding of said nucleic acid to said marker and detecting the marker so bound, the presence of bound marker indicating the presence of the nucleic acid.
Dependencies are inferred from the claim text.