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US 5,348,851 AGranted
Method and device for the detection of vessel dilatation components
AssigneeForsvarets Forskningsanstalt
InventorsSvante Odman, Jan-Olof Karlsson, Krister Axelsson, deceased
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Abstract
The present invention relates to a method and a device for the detection of vessel dilatation components. The invention particularly relates to the detection of explosives, such as trinitrotoluene (TNT) and nitroglycerin. A biological detector is used, and precontracted blood vessels or parts thereof function as sensor elements.
Claims17
A method for determining the activity of vessel dilatation components, said method comprising:
- causing contraction of a blood vessel preparation by exposing it to an alpha-adrenoceptor agonist,
- exposing the contracted blood vessel preparation to a vessel dilatation component, and
- determining the relaxation effect on the blood vessel preparation caused by the exposure to the vessel dilatation component.
A device for determination of activity of vessel dilatation components, comprising:
- a blood vessel preparation which has been precontracted by an alpha-adrenoceptor agonist;
- an organ bath holding a physiological buffer solution suitable for the preparation;
- a water bath into which the organ bath is immersed and having a temperature suitable for the preparation;
- a conduit for gas supply to the preparation;
- a tension meter;
- means for the attachment of the preparation to the organ bath and to the tension meter;
- and
- a plotting device for recording changes measured by the tension meter caused by relaxation of the blood vessel.
5 more elements
Dependencies are inferred from the claim text.