Vector for recombinant poxvirus expressing rabies virus glycoprotein
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJoseph J. Esposito, Bernard Moss, Kathleen Brechling
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Abstract
A plasmid vector has been constructed for producing unique vaccinia virus recombinant expressing the gene for rabiesvirus glycoprotein in cells. The recombinant induces production of glycoprotein in substantial amounts for immunization against rabies. Such recombinant could be applied for the production of anti-rabies vaccine and of G antigen antibody and related immunological reagents for research or diagnostic purposes.
Claims20
A plasmid having recombinant DNA comprising a rabies virus glycoprotein G gene operatively linked to a vaccinia P.sub.11 late promoter.
A poxvirus recombinant having incorporated therein a rabies virus glycoprotein G gene operatively linked to a vaccinia P.sub.11 late promoter.
An NYBH strain poxvirus recombinant capable of expressing rabies virus glycoprotein G from Challenge Virus Standard Strain under control of promoter P.sub.11.
Dependencies are inferred from the claim text.