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AssigneesCoopers Animal Health NZ Limited, The University of Melbourne, Ministry of Agriculture & Fisheries
InventorsGavin B. L. Harrison, Robert P. Dempster, Michael D. Rickard, Marshall W. Lightowlers, Kim L. O'Hoy, Kevin S. Johnson, David D. Heath, Stephen B. Lawrence, Jennifer G. Vinton
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This invention relates to polypeptide antigens of T.ovis suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obtained by expression of DNA coding therefor in a recombinant host cell. Aspects of the invention include DNA encoding the antigens, vectors containing the DNA and hosts which express the antigens. The invention also provides antibody and DNA probes for use in identifying protective antigens of cestode parasites other than T.ovis.
An antigenic T. ovis polypeptide essentially free from T. ovis components occurring in nature and running as a 47-52 kDa doublet on SDS-PAGE, which reduces the severity of T. ovis infection in a ruminant.
An antigenic T. ovis polypeptide, 45W, essentially free from T. ovis components occurring in nature and running as a 47-52 kD doublet on SDS-PAGE, which reduces the severity of T.ovis infection in a ruminant, said antigenic polypeptide consisting essentially of the amino acid sequence:
An antigenic T. ovis polypeptide, 45W, essentially free from T. ovis components occurring in nature and running as a 47-52 kDa doublet on SDS-PAGE and reducing the severity of T. ovis infection in a ruminant, said antigenic polypeptide consisting essentially of the amino acid sequence:
Dependencies are inferred from the claim text.