US 5,348,730 AGranted

Method for preparing medicinal aerosol formulation containing coated medicament

AssigneeMinnesota Mining and Manufacturing Company

InventorsDavid J. Greenleaf, Tarlochan S. Purewal, Philip A. Jinks

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Abstract

A method for preparing a self-propelling, powder dispersing aerosol composition comprising at least 0.0001% by weight of a finely-divided solid medicament coated with a non-perfluorinated surface active dispersing agent which constitutes at least 0.0001% by weight of the coated solid material, and suspended in an aerosol propellant in which the non-perfluorinated surface-active dispersing agent is substantially insoluble. Propellant-insoluble non-perfluorinated surfactants are used to prepare stable dispersions of powdered medicament by way of pre-coating the medicament with the surfactant prior to admixture with propellant.

Claims8

Dependent claims

A method for preparing an aerosol composition comprising:

a) coating a finely divided solid drug with non-perfluorinated surface-active dispersing agent in a solvent in which the finely divided solid drug is substantially insoluble to afford a coated solid medicament,
(b) separating the coated solid medicament from the solvent,
(c) drying the coated solid medicament,
(d) dispersing the coated solid medicament in an aerosol propellant substantially free of chlorofluorocarbons and in which the surface active dispersing agent is substantially insoluble such that the aerosol composition comprises from 0,001% to 20% by weight of said coated solid medicament and 0,001% to 50% by weight of the coated solid medicament is the non-perfluorinated surface-active dispersing agent.

1 more element

Dependencies are inferred from the claim text.