3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them

A compound of formula I ##STR49## wherein R is alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or optionally substituted aryl, aralkyl or aralkenyl,

• R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, halogen of atomic number of from 9 to 53, trifluoromethyl, pyrrol-1-yl, cyano, carbamoyl, alkenyl of 2 to 5 carbon atom, alkenyloxy of 3 to 5 carbon atoms wherein the double bond is not attached to the carbon atom adjacent to the oxygen atom, alkanoyl of 2 to 5 carbon atoms, nitro, amino, alkanoylamino of 1 to 5 carbon atoms or alkoxycarbonylamino of 1 to 4 carbon atoms in the alkoxy moiety thereof,
• R.sub.2 is hydrogen or has the significance indicated above for R,
• A is alkylene,
• X is a bond
• Y is an oxygen or a sulfur atom and either Z is an oxygen atom and n is 2 or 3 or Z is a bond and n is 1, 2 or 3,
• with the provisos that
• when R.sub.2 is cycloalkylalkyl and R is alkyl then R.sub.1 is other than hydrogen,
• and when R.sub.2 is hydrogen, then Z is an oxygen atom,
• or physiologically acceptable hydrolyzable derivative thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form,
• or a pharmaceutically acceptable salt form thereof.