6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles

Compounds of the formula ##STR15## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, cyclopropylmethyl, aryl (C.sub.1 -C.sub.4 alkyl), --(CH.sub.2).sub.n S(C.sub.1 -C.sub.4 alkyl), --C(O)R.sup.4 or --(CH.sub.2).sub.n C(O)NR.sup.5 R.sup.6 ;

• R.sup.2 is hydrogen, C.sub.1 -C.sub.4 alkyl, cyclopropylmethyl or C.sub.3 -C.sub.4 alkenyl;
• R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl or an amino blocking group;
• n is 1-4;
• R.sup.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy or phenyl;
• R.sup.5 and R.sup.6 are independently hydrogen, C.sub.1 -C.sub.4 alkyl, or C.sub.5 -C.sub.8 cycloalkyl with the proviso that when one of R.sup.5 or R.sup.6 is a cycloalkyl the other is hydrogen;
• and
• HET is an isoxazolyl or substituted isoxazolyl ring;
• or pharmaceutically acceptable salts thereof.