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US 5,347,001 AGranted
Process for preparing sulphonylpristinamycin II.sub.B
AssigneeRhone-Poulenc Rorer S.A.
InventorXavier Radisson
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Abstract
Method for preparing (dialkylamino-2 alkyl)sulphonyl-26 pristinamycin II.sub.B having general formula (I) ##STR1## by oxidation of (dialkylamino-2 alkyl)thio-26 pristinamycin II.sub.B with 3,5 to 20 of hydrogenperoxide equivalent, in the presence of alcaline metal tungstate, in a 2-phase medium, at a temperature between 10.degree. and 25.degree. C.
Claims4
A process for preparing 26-[(2-dialkylaminoalkyl)sulphonyl]pristinamycin II.sub.B of formula:
- ##STR4## in which Alk represents a linear or branched alkylene radical and R represents linear or branched alkyl radicals, these radicals containing 1 to 10 carbon atoms, comprising oxidation of 26-[(2-dialkylaminoalkyl)thio]-pristinamycin II.sub.B of formula:
- ##STR5## in which Alk and R are defined as above, with 3.5 to 20 equivalents of hydrogen peroxide in the presence of an alkali metal tungstate, in a two-phase medium, at a temperature of between 10.degree. and 25.degree. C.
Dependencies are inferred from the claim text.