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US 5,346,993 AGranted
Isolated, large latent complexes of TGF-.beta.2 and TGF-.beta.3, and new binding protein for latent form TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3 LTBP-2
AssigneeLudwig Institute for Cancer Research
InventorsKohei Miyazono, Carl-Henrik Heldin, Anders Olofsson
Life of this patent
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Abstract
The invention relates to large latent complexes of TGF-.beta.2 and TGF-.beta.3, and methods for isolating these. The complex consists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.
Claims4
Isolated molecular complex consisting of;
- (i) a molecule of LTBP-2 binding protein, which is immunologically distinct from latent, TGF-.beta.1 binding protein and has a molecular mass of about 150 KDa as determined by SDS-PAGE;
- (ii) dimerized, beta latency associated peptide linked to said LTBP-2 binding protein via a disulphide bond, and;
- (iii) dimerized TGF-.beta., non-covalently associated with said dimerized, beta latency associated peptide.
Dependencies are inferred from the claim text.