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US 5,346,917 AGranted
Thioxanthenone antitumor agents
AssigneeSterling Winthrop Inc.
InventorsTheodore C. Miller, Joseph C. Collins, Kenneth C. Mattes, Mark P. Wentland, Robert B. Perni, Thomas H. Corbett, Joseph W. Guiles
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Abstract
1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.
Claims25
A compound of formula ##STR11## wherein n is 2 or 3;
- R.sup.1 and R.sup.2 are independently lower-alkyl;
- Q is CH.sub.2 N(R.sup.4)SO.sub.2 R.sup.7 ;
- R.sup.4 is hydrogen, lower-alkyl or Ar;
- R.sup.7 is lower-alkyl, or Ar;
- R.sup.8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy;
- and
- Ar is phenyl or phenyl substituted with methyl, methoxyl, hydroxy, halogen or nitro, with the proviso that when n is 2, R.sup.1 and R.sup.2 are ethyl, R.sup.8 is hydrogen and Q is CH.sub.2 NHSO.sub.2 Ar, the Ar group cannot be 4-monosubstituted by methyl or halogen;
- or a pharmaceutically acceptable acid-addition salt or solvate thereof.
5 more elements
N-[[1-[[2-(Diethylamino)ethyl]amino]-7-bromo-9-oxothioxanthen- 4-yl]methyl]methanesulfonamide.
Dependencies are inferred from the claim text.