(4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase

A compound of the formula:

• ##STR59## or a pharmaceutically acceptable salt thereof wherein W is selected from the group consisting of ##STR60## wherein Q is oxygen or sulfur,
• R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl of one to four carbon atoms, provided that when L.sup.1 is a valence bond, R.sup.6 is alkyl of one to four carbon atoms, or
• R.sup.6 and R.sup.7, taken together with the nitrogen atoms to which they are attached, define a radical of the formula ##STR61## R.sup.8 is selected from the group consisting of hydrogen,
• alkyl of one to four carbon atoms,
• haloalkyl of one to four carbon atoms,
• unsubstituted phenyl,
• phenyl substituted with
• alkyl of one to four carbon atoms,
• alkoxy of one to four carbon atoms,
• haloalkyl, or
• halogen,
• hydroxyalkyl of from one to four carbon atoms,
• aminoalkyl of from one to four carbon atoms,
• carboxyalkyl of from one to four carbon atoms,
• (alkoxycarbonyl)alkyl where the alkyl and alkoxy portions each are of one to four carbon atoms,
• (alkylaminocarbonyl)alkyl, where the alkyl and aminoalkyl portions each are of one to four carbon atoms;
• and
• Z is --CH2--, oxygen, sulfur, or --NR9 wherein R9 is hydrogen or alkyl of one to four carbon atoms;
• L.sup.1 is a valence bond or is selected from alkylene of one to three carbon atoms, propenylene, and propynylene;
• R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from the group consisting of
• alkyl of one to four carbon atoms,
• alkoxy of one to four carbon atoms,
• haloalkyl,
• halogen,
• cyano,
• amino,
• alkoxycarbonyl of one to four carbon atoms, and
• dialkylaminocarbonyl where the alkyl portions are each of one to four carbon atoms;
• L.sup.2 is a valence bond or is selected from alkylene of one to three carbon atoms, propenylene, and propynylene;
• Y is selected from the group consisting of
• oxygen,
• >NR10, where R10 is hydrogen or alkyl of one to four carbon atoms, and
• where n=0, 1, or 2;
• and
• R.sup.5 is alkyl of one to four carbon atoms.