Nitrogen-containing cyclohetero cycloheteroaminoaryl derivatives for CNS disorders

A pharmaceutical composition comprising a pharmaceutically-acceptable carrier or diluent and a therapeutically-effective amount of an active compound for preventing neurotoxic damage or treating or preventing cerebral ischemia, psychotic disorder or convulsive disorder, wherein said active compound is a compound of formula ##STR19## or a pharmaceutically acceptable salt thereof, wherein each of R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from the group consisting of methyl, ethyl, propyl, benzyl, and haloloweralkyl of one to five carbon atoms;

• wherein each of R.sup.2, R.sup.3 and R.sup.8 through R.sup.11 is independently selected from hydrido, hydroxy, methyl, ethyl, propyl, benzyl, phenoxy, benzyloxy and haloloweralkyl of one to five carbon atoms;
• wherein n is four or five and m is two or three, with the proviso that when n is four, m is three;
• and
• wherein A is phenyl, naphthyl, benzothienyl, benzofuranyl or thienyl;
• wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydroxy, methyl, ethyl, propyl, methoxy, ethoxy, methylenedioxy, halo, trifluoromethyl, amino, methylamino and dimethylamino.

A method for treating a patient afflicted with or susceptible to neurotoxic damage, cerebral ischemia, psychotic disorder or convulsive disorder, which method comprises administering to the patient a therapeutically-effective amount of a compound of the formula ##STR20## or a pharmaceutically acceptable salt thereof, wherein each of R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from the group consisting of methyl, ethyl, propyl, benzyl, and haloloweralkyl of one to five carbon atoms;

• wherein each of R.sup.2, R.sup.3 and R.sup.8 through R.sup.11 is independently selected from hydrido, hydroxy, methyl, ethyl, propyl, benzyl, phenoxy, benzyloxy and haloloweralkyl of one to five carbon atoms:
• wherein n is four or five and m is two or three, with the proviso that when n is four, m is three;
• and
• wherein A is phenyl, naphthyl, benzothienyl, benzofuranyl or thienyl;
• wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydroxy, methyl, ethyl, propyl, methoxy, ethoxy, methylenedioxy, halo, trifluoromethyl, amino, methylamino and dimethylamino.