Substituted pyridines, their preparation, formulations and use in dementia

A pyridine compound of Formula I below:

• ##STR8## which is substituted on one of the ring carbon atoms with an R.sup.1 azabicyclic ring substituent selected from the group consisting of ##STR9## wherein the broken line represents a single or a, double bond;
• R.sup.3 and R.sup.4 independently represent hydrogen, C.sub.1-4 alkyl, halo, C.sub.1-4 alkoxy, hydroxy, carboxy or C.sub.1-4 alkoxycarbonyl;
• or R.sup.3 and R.sup.4 together represent carbonyl;
• R.sup.2, R.sup.11 and R.sup.12 are each independently selected from the group consisting of hydrogen, halo, --CF.sub.3, --OR.sup.6, --NR.sup.6 R.sup.7, --NHOR.sup.6, --NHNH.sub.2, --CN, COR.sup.8, and the hydrocarbon radicals:
• C.sub.1 -C.sub.15 alkyl, C.sub.2-15 alkenyl, C.sub.2-15 alkynyl, aryl, aralkyl, which in turn are optionally substituted by halo, OR.sup.6, CF.sub.3, NR.sup.6 R.sup.7, --NO.sub.2, keto, SR.sup.6, --SOR.sup.6, SO.sub.2 R.sup.6, CO.sub.2 R.sup.6, CONR.sup.6 R.sup.7, wherein R.sup.6 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl and C.sub.2-6 alkynyl;
• R.sup.7 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl and --COCH.sub.3 and R.sup.8 is selected from the group consisting of --OR.sup.6 and --NR.sup.6 R.sup.7 ;
• and pharmaceutically acceptable salts and prodrugs thereof, provided that the compound is neither 3-hydroxy-3-(2-pyridinyl)-1-azabicyclo[2.2.2]octane nor 3-(2-pyridinyl)-1 -azabicyclo[2.2.2]oct-2 -ene.