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US 5,345,941 AGranted
Contour mapping of spectral diagnostics
AssigneeMassachusetts Institute of Technology
InventorsRichard P. Rava, Rebecca Richards-Kortum, Michael S. Feld, Joseph J. Baraga
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Abstract
The present invention relates to a method of generating and processing spectral information arising from the laser induced fluorescence of tissue. The intensity of fluorescence is recorded as a function of both excitation and emission wavelengths and contour maps of tissue fluorescence are generated which are useful in the diagnosis of condition of the tissue under examination.
Claims18
A method of optically measuring tissue comprising:
- directing light from a broadband light source having a multiplicity of excitation wavelengths onto tissue to induce autofluorescence at a multiplicity of emission wavelengths
- measuring intensities of the induced autofluorescence at the multiplicity of emission wavelengths to produce intensity data;
- generating a contoured electronic representation of the intensity data, the contoured representation being a function of both excitation wavelengths and emission wavelengths;
- correcting the contoured representation by removing a component of the representation correlated with a spectrally absorbing material within the tissue;
- and identifying the presence of a plurality of fluorophores within the tissue from the corrected contoured representation.
2 more elements
A method of optically measuring vascular tissue comprising:
- directing light from a broadband light source having a multiplicity of excitation wavelengths onto vascular tissue to induce autofluorescence at a multiplicity of emission wavelengths;
- measuring intensities of the induced autofluorescence at the multiplicity of emission wavelengths to produce intensity data;
- generating a contoured electronic representation of the intensity data, the contoured representation being a function of both excitation wavelengths and emission wavelengths;
- and
- identifying the presence of a plurality of fluorophores within the tissue from the contoured representation.
2 more elements
A method of optically measuring tissue comprising:
- inserting a fiber optic probe into a body lumen;
- directing light from a broadband light source having a multiplicity of excitation wavelengths through the probe and onto tissue within the lumen to induce autofluorescence at a multiplicity of emission wavelengths;
- collecting induced autofluorescence radiation from the tissue with the fiber optic probe and coupling the collected radiation at a proximal end of the probe to a detector;
- measuring intensities of the induced autofluorescence at the multiplicity of emission wavelengths to produce intensity data;
- generating a contoured electronic representation of the intensity data, the contoured representation being a function of both excitation wavelengths;
- forming a displayed image from the contoured electronic representation;
- and
- identifying the presence of a plurality of fluorophores within the tissue from the contoured representation.
5 more elements
Dependencies are inferred from the claim text.