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US 5,344,940 AGranted
Intermediates for individual stereoisomers of 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones
AssigneeWarner-Lambert Company
InventorsJohn M. Domagala, John S. Kiely, Mel C. Schroeder
Life of this patent
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Abstract
Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
Claims8
An individual stereoisomer of the formula ##STR18## wherein * and *' denote asymmetric carbon atoms;
- R is hydrogen or alkyl of 1-3 carbon atoms;
- and
- R" is hydrogen, alkyl of 1-3 carbon atoms, acetyl, trifluoroacetyl or t-butyloxycarbonyl.
An individual stereoisomer of the formula ##STR19## wherein * and *' denote asymmetric carbon atoms.
3-(Acetyl)-1-(S-.alpha.-methylbenzyl)pyrrolidin-5-one.
3-(2'-(Ethoxycarbonyl)acetyl)-1-(S-.alpha.-methylbenzy l)pyrrolidin-5-one.
Dependencies are inferred from the claim text.