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US 5,344,932 AGranted
N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives
AssigneeThe Trustees of Princeton University
InventorEdward C. Taylor
Life of this patent
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Abstract
N-(Acyl)glutamic acid derivatives in which the acyl group is substituted with 4-hydroxypyrrolo[2,3-d]-pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-[4-(2-{4-hydroxy-6-aminopyrrolo-[2,3-d]pyrimidin-3-yl}ethyl)benzoyl]-L-g lutamic acid.
Claims7
A compound of the formula:
- ##STR14## in which:
- R.sup.1 is --OH or --NH.sub.2 ;
- R.sup.2 is hydrogen or a pharmaceutically acceptable cation:
- R.sup.3 is 1,4-phenylene unsubstituted or substituted with chloro, fluoro, methyl, methoxy, or trifluoromethyl;
- R.sup.4 is hydrogen, or methyl;
- R.sup.5 is amino;
- and
- the configuration about the carbon atom designated * is S.
5 more elements
A compound of the formula:
- ##STR15## in which:
- R.sup.1 is --OH or --NH.sub.2 ;
- R.sup.2' is hydrogen, a pharmaceutically acceptable cation, or a carboxy protecting group:
- R.sup.3 is 1,4-phenylene unsubstituted or substituted with chloro, fluoro, methyl, methoxy, or trifluoromethyl;
- R.sup.4' is hydrogen, or methyl;
- R.sup.5' is amino or amino substituted with an amino protecting group;
- and
- the configuration about the carbon atom designated * is S.
5 more elements
Dependencies are inferred from the claim text.