Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same

A pharmaceutical composition containing a tetrahydrobenzimidazole derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof:

• ##STR62## wherein Het represents a member selected from the group consisting of pyrrolidine, piperidine, piperazine, morpholine, pyrrole, furan thiophene, imidazole, oxazole, thiazole, pyrazole, isoxazole, isothiazole, triazole, thiadiazole, oxadiazole, pyridine, pyridazine, pyrimidine, pyrazine, 4H-cyclopentathiazole, indole, isoindole, 2,3-dihydroindole (indoline), isoindoline, hydroxyindole, indazole, indolizine, benzothiophene, benzofuran, benzothiazole, benzimidazole, benzoxazole, 4,5,6,7-tetrahydrobenzothiophene, 2,3,-dihydrobenzimidazol-2-one, quinoline, isoquinoline, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, 1,4-benzoxazine, phenothiazine, carbazole and .beta.-carboline, and wherein Het may be substituted with 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl lower alkyl aralkyl, lower alkoxy, nitro, hydroxyl, lower alkoxycarbonyl, and halo;
• and X represents a single bond or --NH-- which is bonded to the carbon atom or nitrogen atom of the heterocyclic ring, and a pharmaceutically acceptable carrier.