4-hydroxyquinaldic acid derivatives
AssigneeBoard of Regents, The University of Texas
InventorsAlfred C. Nichols, K. Lemone Yielding
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Abstract
A 7-chloro-4-hydroxy-2-quinoline carbonyl azide and its use as a photoaffinity probe for the N-methyl-D-aspartate (NMDA) receptor complex on neurons are claimed. A number of other compounds, including 4-hydroxy-2-quinoline carbonyl azides, isocyanates, and amides are also provided. Purification and characterization of the NMDA receptor is described.
Claims11
4-hydroxy-2-quinoline carbonyl azide.
A compound according to the formula:
- ##STR10## wherein X.sub.1 and X.sub.2 are the same and each is a halogen.
A compound according to the formula:
- ##STR11## wherein X.sub.1 and X.sub.2 are the same and each is a halogen.
A compound according to the formula:
- ##STR12## wherein X.sub.1 and X.sub.2 are different and are selected from the group consisting of halogen and hydrogen.
A compound according to the formula:
- ##STR13## wherein X.sub.1 is a halogen and X.sub.2 is methyl.
4-hydroxy-2-quinoline carbonyl isocyanate.
A compound according to the formula:
- ##STR14## wherein X.sub.1 and X.sub.2 are the same and each is a halogen.
A compound according to the formula:
- ##STR15## wherein X.sub.1 and X.sub.2 are different and are selected from the group consisting of halogen and hydrogen.
A compound according to the formula:
- ##STR16## wherein X.sub.1 is selected from the group consisting of fluorine, chlorine and bromine and X.sub.2 is methyl.
Dependencies are inferred from the claim text.