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AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJudit Jakus, Myung H. Park, Edith C. Wolff, John E. Folk
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Compositions and methods for the treatment of mammalian cells to inhibit cell growth, especially for inhibiting the proliferative cell growth associated with malignant and non-malignant disease, are provided. More particularly, a deoxyhypusine synthase inhibitor, typically, a mono- or bisguanyl diamine or polyamine, is administered to the cells. Also provided by this invention are diagnostic methods and kits for screening the cells of a patient to determine the effect of the deoxyhypusine synthase inhibitor on proliferation of the cells.
A method for inhibiting the growth of mammalian cells, said method comprising administering a deoxyhypusine synthase inhibitor to the mammalian cells, wherein the deoxyhypusine synthase inhibitor is a compound having the general formula:
A composition for inhibiting the growth of mammalian cells, which composition comprises a deoxyhypusine synthase inhibitor in a pharmaceutically acceptable carrier, wherein the deoxyhypusine synthase inhibitor is a compound having the general formula:
A compound having the formula:
Dependencies are inferred from the claim text.