Steroid sulphatas inhibitors
AssigneeImperial College of Science, Technology and Medicine
InventorMichael J. Reed
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Abstract
Novel steroid 3-thiophosphonates are disclosed which are useful as steroid sulphatase inhibitors.
Claims6
A pharmaceutical preparation comprising in admixture a steroid sulphatase inhibitor and a parenterally administrable carrier wherein the steroid sulphatase inhibitor comprises an effective amount of a steroid-3-thiophosphonate of the formula ##STR5## where R=alkyl, and the ring system ABCD represents a substituted or umsubstituted saturated or unsaturated steroid nucleus, or a pharmaceutically acceptable salt thereof.
A pharmaceutical preparation comprising, in unit dosage form, a steroid sulphatase inhibitor in admixture with an orally administrable carrier, wherein the said steroid sulphatase inhibitor is a steroid-3-thiophosphonate of the formula ##STR6## wherein R is alkyl, and the ring system ABCD represents a substituted or unsubstituted, saturated or unsaturated steroid nucleus, or a pharmaceutically acceptable salt thereof, said preparation containing from 100 to 500 mg of said steroid-3-thiophosphonate or salt per unit dose.
Dependencies are inferred from the claim text.