US 5,344,776 A · DNA encoding an insect octopamine receptor

Abstract

The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.

Claims11

Dependent claims

An isolated DNA segment selected from the group consisting of:

(a) a DNA segment encoding an invertebrate octopamine receptor protein comprising the amino acid sequence set forth in Sequence ID NO:2 and
(b) a DNA segment which is capable of hybridizing to the complement of a DNA segment according to (a) under low stringency hybridization conditions and which encodes an invertebrate octopamine receptor protein.

Dependencies are inferred from the claim text.

DNA encoding an insect octopamine receptor

Life of this patent

DNA encoding an insect octopamine receptor

Life of this patent

Abstract

Claims11