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US 5,344,768 AGranted
Process for the preparation of pyrrolo-quinoline quinone
AssigneeMitsubishi Gas Chemical Company, Inc.
InventorTeizi Urakami
Life of this patent
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Abstract
Pyrrolo-quinoline quinone (PQQ) is microbiologically produced by culturing a bacterium in a medium containing methanol, methylamine or a mixture thereof as a carbon source and recovering PQQ from the culture medium. The bacteria are strains of Methylobacterium, Ancylobacter, Hyphomicrobium, Xanthobacter, Thiobacillus, Microcyclus and Achromobacter.
Claims6
A process for the preparation of pyrroloquinoline quinone which comprises cultivating in a culture medium containing methanol as a carbon source a bacterial strain selected from the group consisting of:
- Methylobacterium organophilum ATCC 29983
- Protomonas extorquens JCM 2802
- Mycoplana rubra NCIB 10409
- Ancylobacter aquaticus ATCC 25396
- Microcyclus eburneus ATCC 21373
- Microcyclus polymorphum NCIB 10516
- Microcyclus methanolica DSM 2666
- Hyphomicrobium variable NCIB 10517
- Hyphomicrobium vulgare NCIB 9698
- Hyphomicrobium methylovorum IFO 14180
- Hyphomicrobium sp. DSM 1869
- Xanthobacter autotrophicus DSM 432
- Xanthobacter flavus NCIB 10071
- Thiobacillus novellus NCIB 10456
- Methanomonas methylovora ATCC 21852
- Methanomonas methylovora subsp. thiaminophila ATCC 21370
- Pseudomonas insueta ATCC 21276
- Alteromonas thalassomethanolica ATCC 33145
- Methylomonas thalassica ATCC 33146
- Methylophaga marina NCMB 2244
- Methylophaga thalassica NCMB 2162
- Methylophaga thalassica NCMB 2163
- Achromobacterr methanophila ATCC 21275
- Methylobacillus glycogenes ATCC 29475
- Methylomonas clara ATCC 31226
- Protaminobacter candidus ATCC 21372
- Protaminobacter thiaminophagus ATCC 21371
- Pseudomonas methanolica ATCC 21704 and
- Pseudomonas methylotropha NCIB 10510
- and recovering pyrroloquinoline quinone from the culture medium.
27 more elements
Dependencies are inferred from the claim text.