DNA encoding polypeptides with activity against gram-positive and gram-negative bacteria
AssigneeXoma Corporation
InventorsJiunu S. Lai, Jar-How Lee, James E. Callaway
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Abstract
The invention relates to cecropin-like polypeptides with a variety of C-terminus modifications. Conversion of the terminal carboxy group to a homoserine extended neutral, negatively charged or positively charged form results in the polypeptides of the invention that have significant bactericidal effects against both Gram-positive and Gram-negative bacteria.
Claims9
A recombinant DNA molecule comprising a genetic sequence coding for a cecropin polypeptide which is extended at the C-terminus thereof by Met-X wherein X is a group which is clearable from methionine by CNBr.
A pharmaceutical composition with antimicrobial activity, comprising an effective amount of a cecropin polypeptide which is extended by a homoserine residue at the C-terminus thereof.
Dependencies are inferred from the claim text.