Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites and production process
AssigneeTeijin Limited
InventorsYorimasa Suwa, Atsushi Imaizumi, Masahiro Okada, Ichiro Kudo, Keizo Inoue, Yoji Suzuki
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Abstract
Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites which have an amino acid sequence given in FIGS. 3-1 through 3-3 or an amino acid sequence physiologically equivalent thereto, a process for preparation of said inhibitory protein wherein serum of mammalian animal is enzymatically treated, and a gene coding said inhibitory protein.
Claims2
A process for preparing a phosphilipase A.sub.2 -inhibitory protein consisting of the amino acid sequence of FIGS. 3-1 through 3--3 comprising:
- (a) obtaining human serum;
- (b) incubating said serum at 37.degree. C. for 6 to 10 days;
- (c) adding a protease inhibitor to said incubated serum;
- and
- (d) purifying said inhibitory protein from said serum.
Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites wherein said inhibitors consist of the amino acid sequence given in FIGS. 3-1 through 3-3.
Dependencies are inferred from the claim text.