Plasma-based platelet concentrate preparations
AssigneeThomas Jefferson University
InventorScott Murphy
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Abstract
The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding storage extension additives to a platelet concentrate.
Claims20
A human blood, plasma-based platelet concentrate preparation for the storage of platelets consisting essentially of:
- (a) platelets;
- (b) plasma and anticoagulant, wherein said plasma and anticoagulant are present in an amount of at least 90 percent by weight of the concentrate preparation;
- and
- (b) acetate, wherein said acetate is present in an amount of from about 5 to about 20 mM.
A human blood, plasma-based platelet concentrate preparation for the storage of platelets consisting of:
- (a) platelets;
- (b) plasma and anticoagulant, wherein said plasma and anticoagulant are present in an amount of at least 90 percent by weight of the concentrate preparation;
- and
- (c) acetate, wherein said acetate is present in an amount of from about 5 to about 20 mM.
A human blood, plasma-based platelet concentrate preparation for the storage of platelets, produced by the process consisting essentially of the steps of suspending platelets in a solution consisting essentially of (i) at least about 90 weight percent plasma and anticoagulant for the plasma, and (ii) from about 5-20 mM acetate.
A human blood, plasma-based platelet concentrate preparation for the storage of platelets consisting of platelets, plasma and anticoagulant for the plasma, and acetate, wherein said acetate is present in an amount of from about 5 to about 20 mM.
Dependencies are inferred from the claim text.