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US 5,344,641 AGranted
Antibacterial antiplaque oral composition
AssigneeColgate-Palmolive Company
InventorsAbdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
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AssigneeColgate-Palmolive Company
InventorsAbdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
Estimating the term…
An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, wherein said antiplaque agent is substantially completely dissolved in saliva present during tooth and gum cleaning in a solubilizing agent therefor. The solubilizing agent may be a humectant polyol such as propylene glycol, dipropylene glycol and hexylene glycol; a cellosolve such as methyl cellosolve and ethyl cellosolve; a vegetable oil or wax containing at least about 12 carbon atoms in a straight chain such as olive oil, castor oil and petrolatum; or an ester such as ethyl acetate, amyl acetate, glyceryl tristearate and benzyl benzoate.
An oral composition dentifrice for attaching, adhering or bonding a plaque-inhibiting antibacterial agent to oral tooth and gum surfaces comprising in an orally acceptable vehicle about 5-30% by weight of a siliceous polishing agent, an effective antiplaque amount in the range of about 0.01-5% by weight of a substantially water insoluble non-cationic antibacterial agent, about 0.05-5% by weight of an antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing, which delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, and about 0.5-50% by weight of a solubilizing material for said antibacterial agent in amount sufficient to dissolve said antibacterial agent in saliva and permit delivery of said antibacterial agent to soft oral tissues at or near the gum line.
An oral composition dentifrice comprising in an orally acceptable vehicle, about 5-30% of a siliceous polishing agent, about 0.01-5% of triclosan, about 0.05-5% of poly(beta-styrenephosphonic acid), poly(alpha-styrenephosphonic acid), or a copolymer of ether styrenephosphonic acid and monomer with the other or with another inert polymerizable ethylenically unsaturated monomer and propylene glycol in amount sufficient to dissolve the triclosan in saliva.
Dependencies are inferred from the claim text.