Continuous particle separation process

A method for the separation of viral inclusion bodies from other solid biological debris in an insect homogenate, comprising the steps of:

• 1) introducing said inset homogenate comprising said viral inclusion bodies and said other solid biological debris to a vibrating mesh screen, said vibrating mesh screen retaining said other solid biological material and passing said viral inclusion bodies;
• 2) a first collecting step of collecting said viral inclusion bodies which are passed through said vibrating mesh screen;
• 3) re-introducing at least a portion of said viral inclusion bodies obtained from said collecting step to said filter means;
• and
• 4) a second collecting step of collecting any said viral inclusion bodies which are passed through said filter means.

A method for the separation of small particles from larger particles in a liquid biological preparation comprising an insect homogenate, said method comprising the steps of:

• 1) introducing said liquid biological preparation comprising said small particles and said larger particles to a filter means, said filter means capable of retaining said larger particles and passing said small particles;
• 2) a first collecting step of collecting said small particles which are passed through said filter means;
• 3) re-introducing at least a portion of said small particles obtained from said collecting step to said filter means;
• and
• 4) a second collecting step of collecting any said small particles which are passed through said filter means.