Device for depletion of the leucocyte content of blood and blood components
AssigneePall Corporation
InventorsDavid B. Pall, Thomas C. Gsell
Life of this patent
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Abstract
A high efficiency leucocyte-depletion filter for use with packed red cell concentrate derived from freshly drawn blood comprises a fibrous filter medium with a pore size of from about 0.5 to less than 3.6 .mu.m and a CWST of from 53 to about 80. The filter is preferably used in conjunction with a gel prefilter and, optionally, a microaggregate filter so as to minimize clogging. In a preferred embodiment, the voids volume is about 60% to about 85%.
Claims24
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential and a pore diameter of from about 0.5 to less than about 2 .mu.m and having a CWST of from 53 to about 80 dynes/cm.
A device for the depletion of the leukocyte content of a fresh blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 .mu.m, a voids volume of about 65% to about 84% and having a CWST of from 53 to about 80 dynes/cm.
A device for the depletion of the leukocyte content of a fresh blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 .mu.m, and a CWST of from about 62 to about 68 dynes/cm.
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter including multilayers, said filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 .mu.m, a CWST of from about 62 to about 68 dynes/cm, and including synthetic fibers having an average diameter of less than 3 .mu.m.
A system for the depletion of the leukocyte content of a blood product comprising a device including a housing having an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, and a fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, the filter having a negative zeta potential and a pore diameter of from about 0.5 to less than about 2 .mu.m and having a CWST of from about 55 to about 80 dynes/cm;
- at least one container in fluid communication with the device;
- and,
- a conduit interposed between the container and the device.
Dependencies are inferred from the claim text.