Graft polymer articles having bioactive surfaces
AssigneeMedtronic, Inc.
InventorsJames R. Keogh, Christopher M. Hobot, John W. Eaton, Allan H. Jevne, Matthew A. Bergan
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Abstract
Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm)m and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.
Claims8
An article for use in contact with blood or blood products, the article including at least one biocompatible polymeric surface for contacting blood or blood products, the polymeric surface having thereon a first layer and a second layer, the first layer comprising a graft co-polymer grafted onto the polymeric surface by co-polymerizing a first vinyl monomer selected from the group consisting of 2-acrylamido-2-methylpropane sulfonic acid, acrylamide, acrylic acid, and 2-hydroxyethyl methacrylate with a second vinyl monomer of N-(3-aminopropyl) methacrylamide hydrochloride which provides the graft co-polymer with pendant primary amine groups, the second layer comprising a bioactive agent selected from the group consisting of antibiotics, antimicrobials, anticoagulants and albumin-binding dyes coupled to the graft co-polymer by coupling to its primary amine groups.
Dependencies are inferred from the claim text.