Method for manufacturing freeze dried dosages in a multilaminate blister pack

A method for packaging a freeze-dried dosage formed from a liquid comprising the steps of:

• a) forming a first polymeric sheet;
• b) forming a second polymeric sheet having substantially the same coefficient of thermal expansion as the first polymeric sheet;
• c) forming an aluminum sheet;
• d) sandwiching the aluminum sheet between the first and second polymeric sheets to form a multilayer blister film defining a film plane, the multilayer blister film providing a substantially thermally balanced laminate;
• e) forming a plurality of depressions in the multilayer blister film;
• f) introducing the liquid into the depressions;
• g) freezing the liquid, the thermally balanced laminate substantially avoiding warpage of the film plane interposed between the depressions;
• h) freeze drying to provide the freeze-dried dosage;
• and
• i) attaching a lidding sheet to the multilayer blister film to seal the depressions thereof.