Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties
AssigneeFisons Limited
InventorsRichard J. Schmiesing, Robert J. Murray
Life of this patent
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Abstract
Compounds of the formula I, ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently represent hydrogen, alkyl, phenyl or substituted phenyl with the proviso that two of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 are phenyl or substituted phenyl and two of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 are hydrogen or alkyl; m represents an integer from 1-2; and n represents an integer from 1-3; or a pharmaceutically acceptable salt thereof. The compounds are useful as pharmaceuticals, in particular, in the treatment of epilepsy.
Claims4
A compound of formula I ##STR8## wherein R.sub.1 and R.sub.2 independently represent phenyl or phenyl substituted by one or more groups selected from halogen, hydroxyl, nitro, amino, C.sub.1-6 alkyl and C.sub.1-6 alkoxy;
- R.sub.3 and R.sub.4 independently represent hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sub.5 and R.sub.6 independently represent hydrogen, C.sub.1-6 alkyl or C.sub.3-6 cycloalkyl, or R.sub.5 and R.sub.6 together with the nitrogen form a C.sub.4-6 N heterocycle;
- m represents an integer from 1-2;
- and
- n represents an integer from 1-3;
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.