US 5,334,601 AGranted

Soft .beta.-adrenergic blocking agents

OwnerNicholas S. Bodorinventor

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Abstract

New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p - or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p - (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.

Claims14

Dependent claims

A compound of the formula ##STR301## or a pharmaceutically acceptable acid addition salt thereof, wherein:

n is one;
R is C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p - consisting of a two or three ring bridged or fused saturated alicyclic hydrocarbon system bearing 0 to 3 methyl substituents and having a total of 6 to 18 carbon atoms in the polycycloalkyl portion and p is zero, one or two;
or R is C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p - consisting of a two or three ring bridged or fused unsaturated alicyclic hydrocarbon system bearing 0 to 3 methyl substituents and having a total of 6 to 18 carbon atoms in the polycycloalkenyl portion and p is zero, one or two;
R.sub.1 is C.sub.1 -C.sub.7 alkyl;
and
Ar is a divalent fused ring system having two or three rings and at least one benzene nucleus, and optionally having one or two hetero ring atoms selected from the group consisting of N, O and S.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 07/997,248Filed 28 Dec 1992 · division
Priority: CA 0747639113 Mar 1985
Granted: 2 Aug 1994
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07C 217/36
The six-membered aromatic ring or condensed ring system containing that ring being further substituted: by carbon atoms having at least two bonds…
C07C 69/732
Of unsaturated acids: of unsaturated hydroxy carboxylic acids
C07C 235/06
The carbon skeleton being acyclic and saturated: having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon…
C07D 209/18
With substituted hydrocarbon radicals attached to carbon atoms of the hetero ring: radicals substituted by carbon atoms having three bonds to…

Family

Serial589,359Parent of this continuation-in-part · filed 14 Mar 1984
Serial741,846Parent of this continuation · filed 6 Jun 1985
Serial922,462Parent of this division · filed 23 Oct 1986
Serial286,879Parent of this continuation · filed 20 Dec 1988
Serial692,260Parent of this division · filed 26 Apr 1991
Serial822,127Parent of this division · filed 17 Jan 1992
US 5,202,347 AParent of this division
US 5,135,926 AParent of this division
US 4,829,086 AParent of this division
US 5,334,601 AThis patent

From the US filing history. Foreign family members aren’t listed.

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