Tricyclic thienothiopyran carbonic anhydrase inhibitors

A compound of structural formula ##STR52## having a cis configuration, the enantiomers and mixtures thereof, or an ophthalmologically acceptable salt thereof wherein:

• R is:
• ##STR53## R.sub.1 is:
• 1) H;
• 2) C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.1-6 alkyl substituted with F, OH, C.sub.1-5 alkyl-S(O).sub.m -- or C.sub.1-5 alkyl-O--;
• 3) phenyl or benzyl wherein the phenyl groups optionally are substituted by C.sub.1-3 alkyl, halogen, CF.sub.3, OH, or C.sub.1-3 alkoxy;
• R.sub.2, R.sub.3, R.sub.5, R.sub.6, and R.sub.7 are independently H or C.sub.1-4 alkyl or R.sub.2 and R.sub.3 together are .dbd.O;
• and
• R4 is
• 1) H or C.sub.1-6 alkyl;
• 2) C.sub.1-6 alkyl substituted with
• a) hydroxy,
• b) C.sub.1-3 alkyl-O--,
• c) hydroxy-C.sub.1-3 alkyl-O--,
• d) C.sub.1-3 alkyl-O--C.sub.1-3 alkyl-O--,
• e) hydroxy-C.sub.1-3 alkyl-O--C.sub.1-3 alkyl-O--,
• f) (C.sub.1-3 alkyl).sub.2 -N--,
• g) hydroxy-C.sub.1-3 alkyl-NH--,
• h) C.sub.1-3 alkyl-O--C.sub.1-3 alkyl-NH--,
• i) hydroxy-C.sub.1-3 alkyl-O--C.sub.1-3 alkyl-NH--,
• j) C.sub.1-3 alkyl-S(O).sub.m --,
• k) hydroxy-C.sub.1-3 alkyl-S(O).sub.m --,
• l) C.sub.1-3 alkyl-O--C.sub.1-3 alkyl-S(O).sub.m --,
• m) hydroxy-C.sub.1-3 alkyl-O--C.sub.1-3 alkyl-S(O).sub.m --,
• n) C.sub.1-3 alkyl-S(O).sub.m -C.sub.1-3 alkyl-O--,
• o) hydroxy-C.sub.1-3 alkyl-S(O).sub.m --C.sub.1-3 alkyl-O--,
• p) C.sub.1-3 alkyl-S(O).sub.m --C.sub.1-3 alkyl-S(O).sub.m --
• q) hydroxy-C.sub.1-3 alkyl-S(O).sub.m --C.sub.1-3 alkyl-S(O).sub.m --,
• 3) C.sub.2-3 alkenyl or C.sub.2-6 alkenyloxy;
• m and n are 0, 1, or 2.