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AssigneeHoechst Celanese Corporation
InventorsApurba Bhattacharya, John R. Fritch, Carl D. Murphy, Larry D. Zeagler, Carina Araullo-McAdams
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There is disclosed and claimed a process whereby S(+)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a molar equivalent of the quantity of S(+)-ibuprofen in the ibuprofen enantiomeric mixture. The mother liquors after separating the above salt are enriched in R-ibuprofen which is racemized by a novel thermal racemization process and may then be recycled.
A process for racemization of an enantiomerically enriched .alpha.-arylcarboxylic acid, said process comprising heating said enantiomerically enriched .alpha.-arylcarboxylic acid at about 100.degree.-300.degree. C. for about 1-10 hours, in the substantial absence of other components.
A process for racemization of an enantiomerically enriched .alpha.-arylcarboxylic acid, said process comprising heating said enantiomerically enriched .alpha.-arylcarboxylic acid at about 100.degree.-300.degree. C. for about 1-10 hours, in the substantial absence of solvent.
A process for separation of an .alpha.-acrylcarboxylic acid of the formula Ar(R)CHCO.sub.2 H from an amino acid, said process comprising:
Dependencies are inferred from the claim text.