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US 5,332,759 AGranted
Naphthalene amides and sulphonamides, processes for their preparation and pharmaceutical compositions containing them
AssigneeAdir et Compagnie
InventorsPatrick Depreux, Daniel Lesieur, Habib Abdellaoui, Beatrice Guardiola, Gerard Adam, Pierre Renard, Bruno Pfeiffer
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Abstract
The invention relates to compounds of the general formula (I): ##STR1## wherein R.sub.3 represents a group ##STR2## R.sub.1, R.sub.2, R.sub.6, R.sub.7 being as defined in the description. Medicinal product useful in treating a disorder due to vasodilatation of the vascular system.
Claims11
A compound selected from those of the formula (I):
- ##STR61## it being possible for each of the two substituents, independently of the other, to be located on either one of the two naphthalene rings, and wherein
- R.sub.1 and R.sub.2, which are the same different, each represents, independently of the other, a radical selected from:
- hydrogen,
- straight-chain or branched alkyl having 1 to 6 carbon atoms, inclusive,
- cycloalkyl, having 3 to 7 carbon atoms, inclusive, or cycloalkyl(C1-C4)alkyl,
- straight-chain or branched alkyl having 2 to 6 carbon atoms inclusive,
- optionally substituted aryl,
- and optionally substituted aralkyl of which the alkyl chain has 1 to 3 carbon atoms, inclusive,
- R.sub.3 represents:
- ##STR62## wherein R.sub.6 and R.sub.7, which are the same or different, have the same definition as R.sub.1 and R.sub.2,
- an optical isomer therefore,
- and an addition salt with a pharmaceutically-acceptable mineral or organic acid;
- "aryl" meaning a group selected from phenyl, naphthyl;
- the expression "optionally substituted meaning that the aromatic nucleus or nuclei may be substituted by one or more radicals selected from hydroxy, halogen, trifluoromethyl, nitro, straight-chain or branched alkyl having 1 to 6 carbon atoms, inclusive, and straight-chain or branched alkoxy having 1 to 6 carbon atoms, inclusive.
11 more elements
Dependencies are inferred from the claim text.