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US 5,332,732 AGranted
Thiophene and pyridine antipsychotic agents
AssigneeMcNeilab, Inc.
InventorsMalcolm K. Scott, Allen B. Reitz, Frank J. Villani, Jr., C. Royce Rasmussen
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Abstract
Compounds of the general formula I ##STR1## wherein A is N; Ar is aryl, substituted aryl or benzofuranyl, wherein the substituents are selected from C.sub.1 -C.sub.8 alkoxy; B is CO or CH.sub.2 and HET is selected from any of piperizine, piperidine, hexahydroazepine, morpholine, thiomorpholine or pyrrolidine, which may be substituted with one of more oxo groups are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I are also disclosed.
Claims22
A compound of the formula I:
- ##STR7## wherein A is N
- Ar is aryl substituted aryl or benzofuranyl, wherein the aryl substituents are seleted from C.sub.1 -C.sub.8 alkoxy;
- B is CO or CH.sub.2 ;
- W is thiophene or pyridine;
- HET is selected from any of piperizine, piperidine, hexahydroazepine, morpholine, thiomorpholine or pyrrolidine, which may be substituted with one or more oxo groups, or the pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.