US 5,332,675 A · Optically active aromatic carboxylic acid derivatives and process for producing the same

Abstract

Disclosed are optically active aromatic carboxylic acid derivatives represented by the formula (I): ##STR1## (wherein R.sub.2 represents an alkoxyalkyl group having 1 to 20 carbon atoms or an alkyl group having 1 to 20 carbon atoms, which alkyl group may be substituted with a halogen atom; l represents a number of 1 or 2; m represents a number of 0 or 1; and * indicates asymmetric carbon atom) and a process for producing such derivatives through the following reaction steps: ##STR2## A process for the hydrolysis of ester derivatives of (I) using esterase is described. The optically active aromatic carboxylic acid derivatives represented by the above-described formula (I) are useful as a liquid crystal material and can be also utilized as an intermediate for the preparation of pharmaceuticals, agricultural chemicals and the like.

Claims8

Dependent claims

A process for preparing an optically active alcohol of the formula:

##STR26## (wherein R.sub.1 represents a lower alkyl group or ##STR27## wherein Z represents a hydrogen atom, a halogen atom or a lower alkyl or lower alkoxyl group;
l represents a number of 1 or 2;
and * indicates asymmetric carbon atom) comprising subjecting an ester represented by the formula:
##STR28## (wherein R.sub.1 and l are as defined above, and R" represents a lower alkyl group) to asymmetric hydrolysis by using an esterase having the ability to hydrolyze one of the enantiomers of said ester, said esterase being derived from an animal or a plant and selected from the group consisting of swine liver esterase, steapsin, pancreatin and wheat germ esterase.

1 more element

Dependencies are inferred from the claim text.

Optically active aromatic carboxylic acid derivatives and process for producing the same

Life of this patent

Optically active aromatic carboxylic acid derivatives and process for producing the same

Life of this patent

Abstract

Claims8