Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these
AssigneeBASF SE
InventorsHans-Heiner Wuest, Bernd Janssen
Life of this patent
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Abstract
Compounds of the general formula I ##STR1## and drugs and cosmetics prepared therefrom are described.
Claims11
A compound of the formula I ##STR16## where A is ethylene or methylene which can be substituted by methyl, hydroxyl or oxo,
- L is one of the following ##STR17## R.sup.1 and R.sup.2 are hydrogen or methyl, R.sup.3 is hydrogen, hydroxyl or C.sub.1 -C.sub.6 -alkoxy,
- R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,
- R.sup.5 is hydrogen, or methoxy, and
- R.sup.6 is ##STR18## or CHR.sup.7 --OH where
- R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,
- R.sup.11 is hydrogen, C.sub.1 -C.sub.4 -alkyl, or --OR.sup.13 or --NR.sup.14 R.sup.15 where R.sup.13 is hydrogen, C.sub.1 -C.sub.8 -alkyl, which can be substituted by 1 or 2 hydroxyls, or aryls or aralkyl, each of which can be substituted in the aryl moiety by a substituent selected from the group consisting of methyl, methoxy, cyano, and halogen, and where R.sup.14 and R.sup.15 are hydrogen, or aralkyl or aryl which can be substituted by a substituent selected from the group consisting of methyl, methoxy, cyano, and halogen, or R.sup.14 and R.sup.15 form, together with the nitrogen to which they are bonded, a 5- or 6-membered saturated heterocyclic radical, or a 5- or 6- membered saturated heterocyclic radical which has an oxygen in addition to the nitrogen, and R.sup.12 is C.sub.1 -C.sub.4 -alkyl, and the physiologically tolerated salts thereof.
1-(4-Carbomethoxyphenyl)-3-(5,6,7, 8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthyl)-1,3-propanedione.
1-(4-Carboxyphenyl)-3-(5,6,7, 8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthyl)-1,3-propanedione.
A method of treating a dermatological disorder associated with pathological keratinization, precancerose, carcinoma, corneopathy, rheumatic disorder or arthritic disorder, comprising topically administering said composition according to claim 13 to a patient in need thereof.
A method of treating a dermatological disorder associated with pathological keratinization, precancerose, carcinoma, corneopathy, rheumatic disorder or arthritic disorder, comprising systematically administering said composition according to claim 13 to a patient in need thereof.
Dependencies are inferred from the claim text.