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US 5,276,177 AGranted
Physiologically active substance
AssigneesTetsuya Matsuno, Mpi Corporation
InventorsMayumi Yoshida, Yutaka Saito, Tetsuya Matsuno
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Abstract
A novel physiologically active substance is represented by the formula. ##STR1## The substance is preferably derived from propolis, has excellent antitumor activity and is useful as an antitumor drug.
Claims1
A compound represented by the formula (I):
- ##STR8## and characterized by the following physical and chemical properties:
- (a) Specific rotatory power:
- .sub.D.sup.25 =-83.degree. (c=0.44, methanol)
- (b) Ultraviolet absorption spectrum:
- (in methanol) .lambda.max:
- 212 nm (.epsilon.=4,600, 288 nm) (.epsilon.=2,600)
- (c) Infrared absorption spectrum:
- (KBr tablet method) .nu.(cm.sup.-1):
- 3,600-2,400, 3,450, 2,941, 1,695, 1,641, 1,439, 1,385, 1,259
- (d) Solubility:
- Soluble in methanol, ethyl acetate, chloroform and DMSO. Sparingly soluble in acidic water
- (e) Color reaction:
- Positive to an iodine reagent, a BCG reagent and a cerium sulfate reagent
- (f) High performance liquid chromatography:
- Reversed phase silica gel filler column:
- (ODS, spherical, 5 .mu.m, pore diameter 60 angstrom, 6.0 mm.phi..times.150 mm);
- eluent:
- 0.02M acetic acid-ammonium acetate (pH 5.0)-methanol;
- flow rate 1 ml/min;
- detection:
- detected by means of 240 nm ultraviolet absorption;
- retention time;
- 16.7 minutes.
20 more elements
Dependencies are inferred from the claim text.