Reconstitutable lyophilized protein formulation
AssigneeGenentech, Inc.
InventorsChung C. Hsu, Hoc M. Nguyen, Sylvia S. Wu
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Abstract
A formulation for proteins is provided that comprises a lyophilized mixture of a protein, a water-soluble etherified cellulose in an amount that upon reconstitution of the formulation will be sufficient to form a gel, and an excipient to facilitate rehydration of the gel and to maintain protein integrity during storage of the lyophilized gel product. When reconstituted to a gel, this formulation can be applied, for example, to tissue in need of treatment.
Claims13
A formulation comprising tissue factor, glycerol, and a water-soluble etherified cellulose in an amount that upon reconstitution of the mixture will form a topical gel.
A method for treating tissue comprising the steps of:
- (a) providing a formulation comprising a lyophilized mixture of tissue, factor, glycerol, and a water-soluble etherified cellulose in an amount that upon reconstitution of the mixture will form a topical gel,
- (b) reconstituting the mixture in a sufficient amount of water to form a gel, and
- (c) applying a therapeutically effective amount of the gel topically to the tissue.
A method of modulating the reproductive physiology of mammals during pregnancy and parturition comprising administering to the cervix or vagina a therapeutically effective amount of a gel that has been reconstituted from a formulation comprising a lyophilized mixture of relaxin, sucrose, and a water-soluble etherified cellulose in an amount that upon reconstitution of the mixture will form a topical gel.
Dependencies are inferred from the claim text.