Collagen-polymer conjugates
AssigneeCollagen Corporation
InventorsWoonza Rhee, Donald G. Wallace, Alan S. Michaels, Ramon A. Burns, Jr., Louis Fries, Frank DeLustro, Hanne Bentz
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Abstract
Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
Claims33
A pharmaceutically acceptable, non-immunogenic composition comprising atelopeptide collagen chemically conjugated to a synthetic hydrophilic polymer.
A composition comprising:
- collagen chemically conjugated to a synthetic hydrophilic polymer having a first end and a second end, said first end being bound to a collagen molecule, and said second end being bound to a growth factor.
A pharmaceutically acceptable, non-immunogenic composition suitable for augmentation of soft tissue, which comprises:
- atelopeptide collagen chemically conjugated to a synthetic hydrophilic polymer;
- and
- a sufficient amount of a fluid pharmaceutically acceptable carrier.
A pharmaceutically acceptable, non-immunogenic, injectable composition suitable for augmentation of soft tissue, which comprises:
- atelopeptide collagen;
- a synthetic hydrophilic polymer having a first and second end, wherein said first and second ends comprise reactive groups capable of forming a covalent bond in situ with an available lysine side chain present in collagen;
- and
- a fluid pharmaceutically acceptable carrier in an amount sufficient to form an injectable composition.
Dependencies are inferred from the claim text.