Cyclodextrin films on solid substrates
AssigneeUop LLC
InventorsRonald P. Rohrbach, Haya Zemel, Mark B. Koch
Life of this patent
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Abstract
A large class of crosslinked cyclodextrin resins soluble in water to an extent under about 200 ppm but soluble in an organic solvent to an extent of at least 0.1 weight percent have good film-forming properties with a wide variety of solid phase substrates. The films exhibit excellent adhesive properties toward virtually all solid surfaces which consequently can be readily coated with a thin film having a multiplicity of cyclodextrin moieties available at the surface for seperation and/or purification. Such coated substrates can be prepared in a variety of sizes, shapes, and cyclodextrin loading quite conveniently and relatively inexpensively.
Claims20
A method of forming a film of a cyclodextrin resin on at least one surface of a solid phase substrate comprising contacting said surface of said solid phase with a solution in an dipolar aprotic organic solvent of a crosslinked cyclodextrin, said crosslinked cyclodextrin being a complexing agent with the complexing properties of the non-crosslinked cyclodextrin, being the reaction product of a cyclodextrin and a polyfunctional reagent selected from the group consisting of activated polycarboxylic acids, polybenzylic halides, divinylsulfones, and .beta.-halohydrins and having a solubility in water at 25.degree. C. of less than about 200 ppm and having a solubility in a dipolar aprotic organic solvent at 25.degree. C. of at least 0.1 weight percent, removing the excess of said solution from said surface, and evaporating the dipolar aprotic organic solvent to leave a film of the crosslinked cyclodextrin on said surface.
A coated solid comprising a solid phase substrate having a film on at least one of its surfaces amounting to from about 0.1 to about 10 weight percent of a crosslinked cyclodextrin, said crosslinked cyclodextrin being a complexing agent with the complexing properties of the non-crosslinked cyclodextrin, being the reaction product of a cyclodextrin and a polyfunctional reagent selected from the group consisting of activated polycarboxylic acids, polybenzylic halides, divinylsulfones, and .beta.-halohydrins and having a solubility in water at 25.degree. C. of less than about 200 ppm and having a solubility in a dipolar aprotic organic solvent at 25.degree. C. of at least 0.1 weight percent.
Dependencies are inferred from the claim text.